Thursday, June 1, 2017

Research Into Tumor Cells and p53-Mediated Transcriptional Regulation




Dr. Sam W. Lee is a longtime Harvard Medical School dermatology professor who holds responsibilities as associate director with the Massachusetts General Hospital’s Cutaneous Biology Research Center. Dr. Sam W. Lee also serves as a National Institutes of Health (NIH) chartered committee member within the oncology program.

Dr. Lee’s primary research focus is on tumor suppressor p53-mediated transcriptional regulation and how this determines whether cells live or die. Through apoptosis (programmed cell death), radiation, and chemo, agents are able to generate genotoxic stress that eliminates tumor cells. At the same time, the transcription factor p53 is activated when cellular stresses occur. This factor governs a number of essential cellular programs, from apoptosis to cell cycle arrest.

The function of p53 extends to post-apoptotic events and its role in quickly and efficiently clearing apoptotic cells helps maintain tolerance when physiological conditions occur and prevent inflammation. This role as master regulator is accomplished though the new target DD1α and enables a dead cell phagocytic engulfment process following ionizing radiation and other apoptotic stresses.

Monday, May 22, 2017

Korean Society for Molecular Biology - Ilchun Memorial Lecture Award


Sam W. Lee is a Harvard professor and accomplished medical researcher in the fields of oncology, molecular biology, and cutaneous biology. A widely published scientist and sought-after speaker, Sam W. Lee is a Korean Society for Molecular Biology (KSMB) Ilchun Memorial Lecture Award winner. 

KSMB is a professional organization dedicated to promoting scientific collaboration and advancement in the field of molecular biology. Since 1989, it has worked to promote ongoing research and offer educational resources to molecular biologists both in and outside of the Korean community.

KSMB presents several awards to outstanding physicians and researchers at its annual meeting each year. These include the Ilchun Memorial Lecture Award, which is named in honor of professor Ki-Nyung Lee, who was better known by his pen name “Ilchun.” The award is presented to a leading scientist from overseas. Each year's winner is invited to address the KSMB during a special lecture at the annual meeting.

Friday, May 12, 2017

MLS Fans Suggest Footy McFooty Face as Name for San Diego's Team


Aside from his work as the associate director of the Harvard Cutaneous Biology Research Center at Massachusetts General Hospital, Dr. Sam W. Lee also serves as an associate professor of dermatology at Harvard Medical School. Outside of Sam W. Lee’s professional life, he enjoys watching American soccer. 

With Major League Soccer (MLS) set to expand their number of teams in the coming years, fans in San Diego, California, are hopeful that the Southern California city will get in on the action. They are also hopeful that the team will be named, “Footy McFooty Face,” according to an online poll. 

If the name sounds slightly familiar, it might be because the series of events mirrors a similar poll last year, where the Internet voted to name a $300 million British research ship Boaty McBoatface. That poll was rejected by the United Kingdom’s Science Minister, who said the important vessel needed a more “suitable” name. 

Still, Footy McFooty Face leads the poll with over 7,000 votes, while the nearest alternative is the less silly San Diego Surf with less than half that number of votes. FS Investors, the group behind the poll, will submit the top 10 results to the MLS for review, but like Boaty McBoatface, fans probably should not expect San Diego’s soccer team to don a Footy McFootyface kit, whether it leads the polls or not.

Wednesday, April 12, 2017

The American Association for Cancer Research Annual Meeting


As associate director of the Cutaneous Biology Research Center at Massachusetts General Hospital in Boston, Dr. Sam W. Lee works directly with a multidisciplinary team of investigators dedicated to advancing the understanding of biology. Additionally, Dr. Sam W. Lee is an associate professor of dermatology at Harvard Medical School and a member of several professional organizations, including the American Association for Cancer Research (AACR).

The AACR held its 2016 annual meeting in New Orleans, Louisiana, last April. The theme for the event was “Delivering Cures Through Cancer Science.” 

Sessions emphasized the link between advances in research and improved patient care. At the meeting, numerous discoveries and clinical trials were discussed.

A number of respected speakers took part in the event, including Vice President Joe Biden, who addressed attendees during a plenary session entitled “Highlights 2016: Vision for the Future.” Vice president Biden expressed thanks for the dedicated work of everyone present and encouraged the group to continue the fight for the eradication of cancer.

Wednesday, March 22, 2017

Opera Etiquette Tips


Sam W. Lee, PhD, brings substantial experience to his roles as the associate director of the Cutaneous Biology Research Center at Massachusetts General Hospital and an associate professor of dermatology at Harvard Medical School. Moreover, Dr. Sam W. Lee is an avid operagoer in his free time. As first-time operagoers may be unfamiliar with opera etiquette, here are some tips.

1. Grant the overture the respect it deserves and listen in silence. Applause is generally reserved for the arias that highlight the performance.

2. Don’t obsess about dress; while many enjoy dressing up, you don’t necessarily have to follow their example. Many will arrive in more casual attire.

3. Remember Italian gender linguistics. When praising a male performance, shout “bravo,” but use “brava” for a female performance. “Bravi” is the acceptable form of praise for a group performance. Alternatively, you could whistle, shout, or remain silent.

4. Although opera running times can vary substantially, they usually fall in the two- to three-hour range. It is advisable to eat beforehand.

Monday, March 13, 2017

Three Must-Visit Historical Sites Around the World


Sam W. Lee teaches at Harvard Medical School as an associate professor. He also serves as the associate director of the nearby Cutaneous Biology Research Center, operated by Massachusetts General Hospital. When he finds time away from work, Sam W. Lee enjoys traveling. He is especially fond of visiting historical sites of note.

Many of the world's oldest and most influential historical sites are open or partially open to tourists. If you enjoy world history, consider visiting one of the following historical sites on your next vacation. 

- Angkor Wat in Cambodia. This 12th-century temple, built by King Suryavaraman II, is a prime example of Khmer-era architecture. The beautiful edifices draw many tourists, so it is best to visit early or late in the day.

- Stonehenge in England. More than 3,000 years old, this well-known monument is full of mysteries. Scholars know that the stones comprising the structure came from Wales, but they do not know how they got to their present location or why they were placed there. A fence prevents visitors from walking inside the circle of stones, but the view is still worth a trip.

- Petra in Jordan. Formerly the capital of the Nabataean Empire for more than 500 years, this 6th-century BC wonder was carved directly into a sandstone cliff. It is now a UNESCO World Heritage Site and very welcoming to tourists.

Friday, March 3, 2017

Seborrheic Keratosis Characteristics





Sam W. Lee attended the University of California to pursue his Ph.D. in genetics. Additionally, he went on to study cancer genetics at Harvard Medical School in Boston, Massachusetts. Currently, Sam W. Lee serves as an associate biologist at Massachusetts General Hospital. One of his focus areas is dermatology.

Dermatology is the branch of medicine that provides diagnosis and treatment for skin conditions such as seborrheic keratosis. A common, benign skin growth, middle-aged adults and older adults may notice these growths more. While it’s common to have multiple growths with seborrheic keratosis, some people may experience just one.

As the growths start to appear, they may develop throughout the body, and appear on the back, abdomen, chest, shoulders, and scalp. Seborrheic keratosis growths start out small with a rough texture. As the growth progresses, it may take on a thick, wart-like appearance. Waxy, raised surfaces are another way to describe these growths. 

If you believe you have this type of growth on your body, it’s important to recognize the texture as it can be hard to distinguish from melanoma growths. It is best to have a doctor evaluate and determine the final diagnosis.